2. Academic Validation
  3. Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template

Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template

  • Bioorg Med Chem Lett. 2003 Jan 20;13(2):257-60. doi: 10.1016/s0960-894x(02)00881-8.
John P Mogensen 1,  Lone Jeppesen,  Paul S Bury,  Ingrid Pettersson,  Jan Fleckner,  Jan Nehlin,  Klaus S Frederiksen,  Tatjana Albrektsen,  Nanni Din,  Steen B Mortensen,  L Anders Svensson,  Karsten Wassermann,  Erik M Wulff,  Lars Ynddal,  Per Sauerberg
Affiliations

Affiliation

  • 1 Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark. jpm@novonordisk.com
PMID: 12482434 DOI: 10.1016/s0960-894x(02)00881-8
Abstract

Using a known dual PPARalpha/gamma activator (5) as a structural template, SAR evaluations led to the identification of triple PPARalpha/gamma/delta activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARalpha/gamma/delta activation.

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