2. Academic Validation
  3. Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation

Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation

  • Planta Med. 2003 Feb;69(2):171-4. doi: 10.1055/s-2003-37705.
Xiang-Dong Gao,  Wen-Cai Ye,  Albert C H Yu,  Yun Zhang,  Ren-Xiang Tan,  Ming Li,  W L Wendy Hsiao
PMID: 12624827 DOI: 10.1055/s-2003-37705
Abstract

Using sodium cyanide (NaCN) and glucose deprivation induced cell injury in PC12 as an injury model, we investigated the protective effects of pulsatilloside A and anemoside A 3 on neurons. The results showed that PC12 cells under the NaCN-injury and glucose deprivation would undergo Apoptosis. Additions of pulsatilloside A and anemoside A 3, at dosages ranging from 0.1, 1 and 10 microg/ml, protected PC12 cells from Apoptosis determined by MTT, LDH release analysis, and flow cytometry measurement.

Figures
Products