2. Academic Validation
  3. A study on the synthesis of antiangiogenic (+)-coronarin A and congeners from (+)-sclareolide

A study on the synthesis of antiangiogenic (+)-coronarin A and congeners from (+)-sclareolide

  • Bioorg Med Chem Lett. 2003 Jun 16;13(12):2009-12. doi: 10.1016/s0960-894x(03)00345-7.
Sangtae Oh 1,  In Howa Jeong,  Woon Seob Shin,  Seokjoon Lee
Affiliations

Affiliation

  • 1 Department of Chemistry, Yonsei University, Wonju 220-710, South Korea.
PMID: 12781184 DOI: 10.1016/s0960-894x(03)00345-7
Abstract

Coronarin A 1, epi-coronarin A 2 and some synthetic intermediates 14a and 14b synthesized from sclareolide exhibit good growth inhibition activities on HUVEC proliferation. In particular, coronarin A 1 and epi-coronarin A 2 effectively suppressed the growth factor induced tube formation of HUVEC at the concentration of 10 micro g/mL.

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