2. Academic Validation
  3. Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity

Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity

  • Bioorg Med Chem Lett. 2003 Aug 18;13(16):2809-11. doi: 10.1016/s0960-894x(03)00529-8.
Paola Barraja 1,  Patrizia Diana,  Antonino Lauria,  Alessandra Montalbano,  Anna Maria Almerico,  Gaetano Dattolo,  Girolamo Cirrincione,  Giampietro Viola,  Francesco Dall'Acqua
Affiliations

Affiliation

  • 1 Dipartimento Farmacochimico, Tossicologico e Biologico Università degli Studi, Via Archirafi 32, 90123 Palermo, Italy.
PMID: 12873520 DOI: 10.1016/s0960-894x(03)00529-8
Abstract

A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.

Figures