2. Academic Validation
  3. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma

  • Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83. doi: 10.1016/0006-291x(92)90842-9.
B A Bernard 1,  J M Bernardon,  C Delescluse,  B Martin,  M C Lenoir,  J Maignan,  B Charpentier,  W R Pilgrim,  U Reichert,  B Shroot
Affiliations

Affiliation

  • 1 Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Valbonne, France.
PMID: 1323296 DOI: 10.1016/0006-291x(92)90842-9
Abstract

The action of retinoids on gene regulation is mediated by three distinct nuclear retinoic acid receptor (RAR) subtypes called RAR alpha, beta and gamma. Since RAR gamma is predominantly expressed in adult skin, specific ligands for this subtype could (i) represent valuable tools to evaluate the biological role of RAR gamma in skin and (ii) provide therapeutic entities with a higher therapeutic index at lower teratogenic risk. Using in vitro binding studies and a functional transactivation assay, we have identified three compounds with high RAR gamma selectivity.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-108527
    98.13%, RARγ agonist