2. Academic Validation
  3. Matlystatins, new inhibitors of typeIV collagenases from Actinomadura atramentaria. II. Biological activities

Matlystatins, new inhibitors of typeIV collagenases from Actinomadura atramentaria. II. Biological activities

  • J Antibiot (Tokyo). 1992 Nov;45(11):1733-7. doi: 10.7164/antibiotics.45.1733.
K Tanzawa 1,  M Ishii,  T Ogita,  K Shimada
Affiliations

Affiliation

  • 1 Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
PMID: 1361486 DOI: 10.7164/antibiotics.45.1733
Abstract

Matlystatin A, the main component of matlystatins, inhibits 92 kDa and 72 kDa typeIV collagenases with IC50 values of 0.3 microM and 0.56 microM, respectively, while 7- to 11-fold greater concentrations are required to inhibit thermolysin and Aminopeptidase M. The inhibition is reversible and competitive with respect to gelatin. It inhibits the invasion of basement membrane Matrigel by human fibrosarcoma HT1080 dose-dependently with an IC50 value of 21.6 microM.

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