2. Academic Validation
  3. New bioactive polyphenols from Theobroma grandiflorum ("cupuaçu")

New bioactive polyphenols from Theobroma grandiflorum ("cupuaçu")

  • J Nat Prod. 2003 Nov;66(11):1501-4. doi: 10.1021/np034002j.
Hui Yang 1,  Petr Protiva,  Baoliang Cui,  Cuiying Ma,  Scott Baggett,  Vanessa Hequet,  Scott Mori,  I Bernard Weinstein,  Edward J Kennelly
Affiliations

Affiliation

  • 1 Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, USA.
PMID: 14640528 DOI: 10.1021/np034002j
Abstract

Activity-guided fractionation of Theobroma grandiflorum ("cupuaçu") seeds resulted in the identification of two new sulfated flavonoid glycosides, theograndins I (1) and II (2). In addition, nine known flavonoid Antioxidants, (+)-catechin, (-)-epicatechin, isoscutellarein 8-O-beta-d-glucuronide, hypolaetin 8-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide 6' '-methyl ester, quercetin, kaempferol, and isoscutellarein 8-O-beta-d-glucuronide 6' '-methyl ester, were identified. Theograndin II (2) displayed antioxidant activity (IC(50) = 120.2 microM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay, as well as weak cytotoxicity in the HCT-116 and SW-480 human colon Cancer cell lines with IC(50) values of 143 and 125 microM, respectively. While 1 was less active as an antioxidant than 2, the known compounds were more potent in the DPPH assay (IC(50) range 39.7-89.7 microM).

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