2. Academic Validation
  3. Bioactive flavonoids from Kaempferia parviflora

Bioactive flavonoids from Kaempferia parviflora

  • Fitoterapia. 2004 Jan;75(1):89-92. doi: 10.1016/j.fitote.2003.08.017.
Chavi Yenjai 1,  Khanchara Prasanphen,  Supawadee Daodee,  Varima Wongpanich,  Prasat Kittakoop
Affiliations

Affiliation

  • 1 Faculty of Sciences, Khon Kaen University, Khon Kaen 40002, Thailand. chayen@kku.ac.th
PMID: 14693228 DOI: 10.1016/j.fitote.2003.08.017
Abstract

Nine Flavonoids (1-9) have been isolated from Kaempferia parviflora. Among these, 5,7,4'-trimethoxyflavone (8) and 5,7,3',4'-tetramethoxyflavone (9) exhibited antiplasmodial activity against Plasmodium falciparum, with IC50 values of 3.70 and 4.06 microg/ml, respectively. 3,5,7,4'-Tetramethoxyflavone (7) and compound 8 possessed Antifungal activity against Candida albicans with respective IC50 values of 39.71 and 17.63 microg/ml, and also showed mild antimycobacterial activity with the minimum inhibitory concentrations (MIC) of 200 and 50 microg/ml, respectively. However, none of the isolated compounds demonstrated cytotoxicity against KB, BC and NCI-H187 cell lines.

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