2. Academic Validation
  3. Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480

Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480

  • Bioorg Med Chem Lett. 2004 Mar 22;14(6):1537-41. doi: 10.1016/j.bmcl.2004.01.010.
Gianluca Sbardella 1,  Antonello Mai,  Marino Artico,  Roberta Loddo,  Maria Grazia Setzu,  Paolo La Colla
Affiliations

Affiliation

  • 1 Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.
PMID: 15006398 DOI: 10.1016/j.bmcl.2004.01.010
Abstract

Pursuing our search program for new antitubercular drugs we decided to explore the potentiality of Oxazolidinone moiety by synthesizing novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480. The new derivatives were tested against atypical mycobacteria as well as against drug resistant Mycobacterium tuberculosis and some of them exhibited a fairly good activity against Mycobacterium avium complex (MAC).

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