1. Academic Validation
  2. Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

  • Bioorg Med Chem Lett. 2004 Aug 2;14(15):3861-4. doi: 10.1016/j.bmcl.2004.05.074.
Timothy A Blizzard 1 Frank DiNinno Jerry D Morgan 2nd Helen Y Chen Jane Y Wu Candido Gude Seongkon Kim Wanda Chan Elizabeth T Birzin Yi Tien Yang Lee-Yuh Pai Zhoupeng Zhang Edward C Hayes Carolyn A DaSilva Wei Tang Susan P Rohrer James M Schaeffer Milton L Hammond
Affiliations

Affiliation

  • 1 Merck Research Laboratories, Medicinal Chemistry, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
Abstract

A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.

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