2. Academic Validation
  3. Enantioselective total synthesis of (+)-eupenoxide and (+)-phomoxide: revision of structures and assignment of absolute configuration

Enantioselective total synthesis of (+)-eupenoxide and (+)-phomoxide: revision of structures and assignment of absolute configuration

  • Org Lett. 2004 Jul 8;6(14):2389-92. doi: 10.1021/ol0492288.
Goverdhan Mehta 1,  Subhrangsu Roy
Affiliations

Affiliation

  • 1 Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. gm@orgchem.iisc.ernet.in
PMID: 15228286 DOI: 10.1021/ol0492288
Abstract

[reaction: see text] Stereo- and enantioselective total syntheses of the novel, polyketide Natural Products ent-eupenoxide and ent-phomoxide have been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. These synthetic studies necessitate the revision of the assigned stereostructures of the Natural Products and reveal their absolute configuration.

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