2. Academic Validation
  3. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor

  • FEBS Lett. 2004 Aug 13;572(1-3):167-71. doi: 10.1016/j.febslet.2004.06.097.
Hans Rosenfeldt 1,  José Vázquez-Prado,  J Silvio Gutkind
Affiliations

Affiliation

  • 1 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892-4330, USA.
PMID: 15304342 DOI: 10.1016/j.febslet.2004.06.097
Abstract

We have identified an activator of Rac, P-REX2, that is structurally related to the exchange factor PtdIns(3,4,5)-dependent Rac exchanger (P-REX1), but exhibits distinct tissue-specific expression. P-REX2 is spliced into two RNA species, approximately 3.5 and approximately 10 kb in size. The cDNA corresponding to the smaller transcript encodes a protein that exhibits strong similarity with P-REX1 within its N-terminal domains, but differs in the C-terminal region. P-REX2 promoted increased levels of GTP-bound Rac that could be further stimulated by enhancing PI-3K activity. Thus, P-REX2 may serve as a novel link between Rac activation and the PI-3 kinase pathway.

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