2. Academic Validation
  3. Cytotoxic constituents of roots of Chaerophyllum hirsutum

Cytotoxic constituents of roots of Chaerophyllum hirsutum

  • J Nat Prod. 2004 Sep;67(9):1588-90. doi: 10.1021/np040046w.
Stefano Dall'Acqua 1,  Giampietro Viola,  Sonia Piacente,  Elsa Mariella Cappelletti,  Gabbriella Innocenti
Affiliations

Affiliation

  • 1 Dipartimento di Scienze Farmaceutiche, Università degli Studi di Padova, Via Marzolo 5, 35131 Padova, Italy.
PMID: 15387667 DOI: 10.1021/np040046w
Abstract

Two new lignan derivatives (1 and 2), along with the known scopoletin (3), methyl caffeate (4), falcarindiol (5), 3,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic methyl ester, chlorogenic acid, p-hydroxyphenylethyl-trans-ferulate, and vanillin, were isolated from extracts of the roots of Chaerophyllum hirsutum. Structure elucidation of the new compounds was carried out by 1D and 2D NMR experiments and by HRMS analysis. Several of the isolated compounds were tested for their cytotoxic activity against the HL-60, HT-1080, LoVo, and LoVo/Doxo cell lines.

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