1. Academic Validation
  2. Anti-inflammatory phloroglucinols and terpenoids from Garcinia subelliptica

Anti-inflammatory phloroglucinols and terpenoids from Garcinia subelliptica

  • J Nat Prod. 2004 Nov;67(11):1796-9. doi: 10.1021/np049811x.
Jing-Ru Weng 1 Lo-Ti Tsao Jih-Pyang Wang Ru-Rong Wu Chun-Nan Lin
Affiliations

Affiliation

  • 1 School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
Abstract

Three new phloroglucinols, garcinielliptones K (1), L (2), and M (3), and two new Terpenoids, garcinielliptones N (4) and O (5), have been isolated from the seeds of Garcinia subelliptica. The structures of 1-5 including their relative configurations were elucidated by spectroscopic methods and supported by computer-generated molecular modeling. Compounds 2 and 3 showed potent inhibitory effects on the release of beta-glucuronidase, and on beta-glucuronidase and histamine, respectively, from peritoneal mast cells stimulated with p-methoxy-N-methylphenethylamine (compound 48/80) in a concentration-dependent manner. Compounds 2 and 3 showed potent effects on NO production in culture media of RAW 264.7 cells in response to lipopolysaccharide (LPS). Compound 2 also showed a potent effect on NO production in culture media of N9 cells in response to LPS/interferon-gamma (IFN-gamma).

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