2. Academic Validation
  3. Production of an antiproliferative furanoheliangolide by Lychnophora ericoides cell culture

Production of an antiproliferative furanoheliangolide by Lychnophora ericoides cell culture

  • Chem Pharm Bull (Tokyo). 2004 Dec;52(12):1433-5. doi: 10.1248/cpb.52.1433.
Pierre Alexandre dos Santos 1,  Maria Fernanda Castro Amarante,  Ana Maria Soares Pereira,  Bianca Bertoni,  Suzelei Castro França,  Cláudia Pessoa,  Manoel Odorico de Moraes,  Letícia Veras Costa-Lotufo,  Marcio Roberto Pinho Pereira,  Norberto Peporine Lopes
Affiliations

Affiliation

  • 1 Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão, Preto-SP, Brazil.
PMID: 15577239 DOI: 10.1248/cpb.52.1433
Abstract

This work reports for the first time the production a furanoheliangolide (goyazensolide) by Plant Cell Culture. Monitoring of the goyazensolide metabolism revealed that the maximum production occurred during the lag phase of the Lychnophora ericoides callus culture. The antiproliferative activity of obtained goyazensolide was evaluated against seven Cancer cell lines using MTT assay. The results revealed a potent cytotoxic activity for the furaheliangolide with IC50 values in the range of 0.06 microg/ml for CEM leukemia cells to 0.75 microg/ml for B16 melanome cells.

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