2. Academic Validation
  3. Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa

Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa

  • Arch Pharm Res. 2004 Nov;27(11):1127-31. doi: 10.1007/BF02975117.
Dae Keun Kim 1,  Ki Taek Lee,  Nam-In Baek,  Sung-Hoon Kim,  Hee Wook Park,  Jong Pil Lim,  Tae Yong Shin,  Dong Ok Eom,  Jae Heon Yang,  Jae Soon Eun
Affiliations

Affiliation

  • 1 College of Pharmacy, Woosuk University, Samrye 565-701, Korea. dkkim@woosuk.ac.kr
PMID: 15595415 DOI: 10.1007/BF02975117
Abstract

In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four Isoquinoline Alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract of the aerial parts of Corydalis speciosa. Structures of these compounds were elucidated on the basis of spectroscopic techniques. These compounds inhibited acetylcholinesterase activity in a dose-dependent manner, and the IC50 values of compounds 1-4 were 89.0, 16.1, 5.8, and 3.3 microM, respectively.

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