2. Academic Validation
  3. Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist

Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist

  • Bioorg Med Chem Lett. 2005 Jan 17;15(2):251-4. doi: 10.1016/j.bmcl.2004.11.001.
Yutaka Nakajima 1,  Hitoshi Hamashima,  Ken-Ichi Washizuka,  Yasuyo Tomishima,  Hiroaki Ohtake,  Emiko Imamura,  Toshiko Miura,  Hiroshi Kayakiri,  Masayuki Kato
Affiliations

Affiliation

  • 1 Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6, Kashima 2-Chome, Yodogawa-Ku, Osaka 532-8514, Japan. yutaka_nakajima@po.fujisawa.jp
PMID: 15603933 DOI: 10.1016/j.bmcl.2004.11.001
Abstract

The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.

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