1. Academic Validation
  2. Cytotoxic steroidal saponins from Polygonatum zanlanscianense

Cytotoxic steroidal saponins from Polygonatum zanlanscianense

  • J Nat Prod. 2004 Dec;67(12):1992-5. doi: 10.1021/np049897u.
Jian-Ming Jin 1 Ying-Jun Zhang Hai-Zhou Li Chong-Ren Yang
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Abstract

Four new steroidal saponins, polygonatosides A-D (1-4), were isolated from the rhizomes of Polygonatum zanlanscianense, together with six known spirostanols (5-10) and a known megastigmane glycoside (11). Their structures were elucidated on the basis of spectroscopic analysis and the results of acidic and enzymatic hydrolysis. The cytotoxic activities of 1-11 against HeLa cells are described.

Figures