2. Academic Validation
  3. Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity

Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity

  • Bioorg Med Chem Lett. 2005 May 16;15(10):2575-8. doi: 10.1016/j.bmcl.2005.03.048.
Rômulo P Tenório 1,  Cristiane S Carvalho,  Carla S Pessanha,  José G de Lima,  Antônio R de Faria,  Antônio J Alves,  Edésio J T de Melo,  Alexandre J S Góes
Affiliations

Affiliation

  • 1 Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
PMID: 15863319 DOI: 10.1016/j.bmcl.2005.03.048
Abstract

Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.

Figures