2. Academic Validation
  3. Hirsutide, a cyclic tetrapeptide from a spider-derived entomopathogenic fungus, Hirsutella sp

Hirsutide, a cyclic tetrapeptide from a spider-derived entomopathogenic fungus, Hirsutella sp

  • J Nat Prod. 2005 Aug;68(8):1303-5. doi: 10.1021/np0501536.
Gerhard Lang 1,  John W Blunt,  Nicholas J Cummings,  Anthony L J Cole,  Murray H G Munro
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
PMID: 16124786 DOI: 10.1021/np0501536
Abstract

The entomopathogenic fungus Hirsutella sp., isolated from an infected spider, was found to produce the new cyclotetrapeptide hirsutide (1), cyclo-(L-NMe-Phe-L-Phe-L-NMe-Phe-L-Val), along with the known cytochalasin Q (2), using a cytotoxicity-guided isolation procedure. The structure of 1 was elucidated using one- and two-dimensional NMR experiments, mass spectrometry, and Marfey's method for analyzing the configuration of the Amino acids.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-129642
    Cyclic Tetrapeptide