2. Academic Validation
  3. Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway

Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway

  • Biotechnol Lett. 2005 Jul;27(14):1011-5. doi: 10.1007/s10529-005-7869-x.
Jeong Heon Lee 1,  Seung Bae Rho,  Taehoon Chun
Affiliations

Affiliation

  • 1 Department of Obstetrics and Gynecology, Chonbuk National University Medical School, Keumam Dong, Dukjin Ku, 561-712, Jeonju, South Korea.
PMID: 16132846 DOI: 10.1007/s10529-005-7869-x
Abstract

Programmed cell death 6 (PDCD6) protein is a 22 kDa EF-hand type CA(2+)-binding protein involved in Apoptosis. To define the regulating mechanism of PDCD6 activity in the apoptotic pathway, we searched a human ovary cDNA library for a novel PDCD6 binding protein using a yeast two-hybrid system. The selected protein was the human death-associated protein kinase 1 (DAPk1), another protein that functions as a positive mediator of Apoptosis. Co-transfection of PDCD6 and DAPk1 cDNA into a tumor cell line accelerated Apoptosis via Caspase-3 dependent pathway.

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