2. Academic Validation
  3. 4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300

4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300

  • Phytochemistry. 2005 Dec;66(23):2776-9. doi: 10.1016/j.phytochem.2005.08.014.
Tomoo Hosoe 1,  Toru Iizuka,  Shin-ichirou Komai,  Daigo Wakana,  Takeshi Itabashi,  Koohei Nozawa,  Kazutaka Fukushima,  Ken-ichi Kawai
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Tokyo 142-8501, Japan. hosoe@hoshi.ac.jp
PMID: 16213536 DOI: 10.1016/j.phytochem.2005.08.014
Abstract

Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca2+-induced vasocintraction in aortic rings pretreated with high K+ (60mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic Microorganisms.

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