1. Academic Validation
  2. Immunosuppressive iridoids from the fruits of Gardenia jasminoides

Immunosuppressive iridoids from the fruits of Gardenia jasminoides

  • J Nat Prod. 2005 Nov;68(11):1683-5. doi: 10.1021/np0580816.
Wen-Liang Chang 1 Hua-Ying Wang Li-Shian Shi Jenn-Haung Lai Hang-Ching Lin
Affiliations

Affiliation

  • 1 School of Pharmacy, National Defense Medical Center, National Defense University, Taipei, Taiwan 114, Republic of China. wlchang@ndmctsgh.edu.tw
Abstract

A new iridoid, gardaloside (1), and a new safranal-type monoterpene, jasminoside G (2), together with 10 known compounds including nine Iridoids and a second safranal-type monoterpene, were isolated from the fruits of Gardenia jasminoides. The structures of 1 and 2 were established on the basis of spectroscopic evidence. Of these compounds, geniposide (3), 6alpha-hydroxygeniposide (5), ixoroside (7), and shanzhiside (8) showed significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.

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