2. Academic Validation
  3. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

  • Nat Chem Biol. 2005 Aug;1(3):143-5. doi: 10.1038/nchembio721.
Dorothea Greiner 1,  Tiziana Bonaldi,  Ragnhild Eskeland,  Ernst Roemer,  Axel Imhof
Affiliations

Affiliation

  • 1 Adolf Butenandt Institute, Department of Molecular Biology, Histone Modifications Group, Ludwig-Maximillians University of Munich, Schillerstr. 44, 80336 Munich, Germany.
PMID: 16408017 DOI: 10.1038/nchembio721
Abstract

Histone methylation plays a key role in establishing and maintaining stable gene expression patterns during cellular differentiation and embryonic development. Here, we report the characterization of the Fungal metabolite chaetocin as the first inhibitor of a lysine-specific Histone Methyltransferase. Chaetocin is specific for the methyltransferase SU(VAR)3-9 both in vitro and in vivo and may therefore be used to study heterochromatin-mediated gene repression.

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