1. Academic Validation
  2. Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity

Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity

  • J Nat Prod. 2006 Feb;69(2):277-9. doi: 10.1021/np0503303.
Wei-Lie Xiao 1 Ren-Rong Tian Jian-Xin Pu Xian Li Li Wu Yang Lu Sheng-Hong Li Rong-Tao Li Yong-Tang Zheng Qi-Tai Zheng Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Abstract

A new trinorcycloartane triterpenoid, lancifodilactone H (1), and a new A ring-secocycloartane triterpenoid, lancifoic acid A (2), together with a known compound, nigranoic acid (3), were isolated from the leaves and stems of Schisandra lancifolia. Their structures were elucidated by spectroscopic data analysis. Compound 1 features a biosynthetically modified seven-membered lactone ring, which was confirmed by single-crystal X-ray diffraction. Compounds 1-3 exhibited weak anti-HIV-1 activity in vitro.

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