2. Academic Validation
  3. Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei

Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei

  • J Nat Prod. 2006 Mar;69(3):369-72. doi: 10.1021/np050406v.
Zakaria H Mbwambo 1,  Modest C Kapingu,  Mainen J Moshi,  Francis Machumi,  Sandra Apers,  Paul Cos,  Daneel Ferreira,  Jannie P J Marais,  Dirk Vanden Berghe,  Louis Maes,  Arnold Vlietinck,  Luc Pieters
Affiliations

Affiliation

  • 1 Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.
PMID: 16562837 DOI: 10.1021/np050406v
Abstract

A new biflavanoid, ent-naringeninyl-(I-3alpha,II-8)-4'-O-methylnaringenin (6), along with five known Xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC(50) 6.7 microM). Antitrypanosomal activity (IC(50) 0.87 microM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC(50) 2.0 microM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC(50) 52.3 microM).

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