2. Academic Validation
  3. Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation

Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation

  • Mol Cell Neurosci. 2006 Oct;33(2):160-9. doi: 10.1016/j.mcn.2006.07.007.
Stéphane J Baudouin 1,  Fabien Pujol,  Arnaud Nicot,  Patrick Kitabgi,  Hélène Boudin
Affiliations

Affiliation

  • 1 Institut National de la Santé Et de la Recherche Médicale, I.N.S.E.R.M., Unité 643, I.T.E.R.T, CHU Hotel-Dieu, University of Nantes, 30 Bd Jean Monnet, 44035 Nantes Cedex 01, France.
PMID: 16952464 DOI: 10.1016/j.mcn.2006.07.007
Abstract

The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the Other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains.

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