2. Academic Validation
  3. The TREM receptor family and signal integration

The TREM receptor family and signal integration

  • Nat Immunol. 2006 Dec;7(12):1266-73. doi: 10.1038/ni1411.
Julia Klesney-Tait 1,  Isaiah R Turnbull,  Marco Colonna
Affiliations

Affiliation

  • 1 Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, Missouri 63110, USA.
PMID: 17110943 DOI: 10.1038/ni1411
Abstract

TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.

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