2. Academic Validation
  3. Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists

Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists

  • Bioorg Med Chem Lett. 2007 Feb 15;17(4):937-41. doi: 10.1016/j.bmcl.2006.11.050.
Hee Oon Han 1,  Seung Hae Kim,  Kyoung-Hee Kim,  Gwong-Cheung Hur,  Hyeon Joo Yim,  Hee-Kyung Chung,  Sung Ho Woo,  Ki Dong Koo,  Chang-Seok Lee,  Jong Sung Koh,  Geun Tae Kim
Affiliations

Affiliation

  • 1 Research and Development, LG Life Sciences, 104-1 Munji-dong, Yuseong-gu, Daejon 305-380, Republic of Korea.
PMID: 17157019 DOI: 10.1016/j.bmcl.2006.11.050
Abstract

Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model.

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