2. Academic Validation
  3. Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists

Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists

  • J Med Chem. 2006 Dec 28;49(26):7887-96. doi: 10.1021/jm061273t.
John Regan 1,  Thomas W Lee,  Renée M Zindell,  Younes Bekkali,  Jörg Bentzien,  Thomas Gilmore,  Abdelhakim Hammach,  Thomas M Kirrane,  Alison J Kukulka,  Daniel Kuzmich,  Richard M Nelson,  John R Proudfoot,  Mark Ralph,  Josephine Pelletier,  Donald Souza,  Lijiljana Zuvela-Jelaska,  Gerald Nabozny,  David S Thomson
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, CT 06877, USA. jregan@rdg.boehringer-ingelheim.com
PMID: 17181172 DOI: 10.1021/jm061273t
Abstract

We report on the nuclear receptor binding affinities, cellular activities of transrepression and transactivation, and anti-inflammatory properties of a quinol-4-one and Other A-ring mimetic containing nonsteroidal class of glucocorticoid agonists.

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