2. Academic Validation
  3. 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

  • Bioorg Med Chem Lett. 2007 Jun 15;17(12):3349-53. doi: 10.1016/j.bmcl.2007.03.102.
Mark E Schnute 1,  David J Anderson,  Roger J Brideau,  Fred L Ciske,  Sarah A Collier,  Michele M Cudahy,  MariJean Eggen,  Michael J Genin,  Todd A Hopkins,  Thomas M Judge,  Euibong J Kim,  Mary L Knechtel,  Sajiv K Nair,  James A Nieman,  Nancee L Oien,  Allen Scott,  Steven P Tanis,  Valerie A Vaillancourt,  Michael W Wathen,  Janet L Wieber
Affiliations

Affiliation

  • 1 Global Research and Development, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. mark.e.schnute@pfizer.com
PMID: 17434304 DOI: 10.1016/j.bmcl.2007.03.102
Abstract

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.

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