2. Academic Validation
  3. The first limonoid peroxide in the Meliaceae family: walsuronoid A from Walsura robusta

The first limonoid peroxide in the Meliaceae family: walsuronoid A from Walsura robusta

  • Org Lett. 2007 Jun 7;9(12):2353-6. doi: 10.1021/ol070735+.
Sheng Yin 1,  Xiao-Ning Wang,  Cheng-Qi Fan,  Shang-Gao Liao,  Jian-Min Yue
Affiliations

Affiliation

  • 1 State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
PMID: 17503836 DOI: 10.1021/ol070735+
Abstract

Walsuronoid A (1), a limonoid featuring an unprecedented 3,4-peroxide-bridged A-seco skeleton, together with walsuronoids B (2) and C (3) possessing a rare 18(13-->14)-abeo-limonoid skeleton, was isolated from Walsura robusta. The structures were elucidated by spectroscopic analysis and chemical correlation, and that of 1 was confirmed by single-crystal X-ray diffraction. Biosynthetic pathway of 2 and 3 was proposed and was chemically mimicked. Compounds 1 and 2 showed weak antimalarial activity.

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