1. Academic Validation
  2. Orphan nuclear receptors in drug discovery

Orphan nuclear receptors in drug discovery

  • Drug Discov Today. 2007 Jun;12(11-12):440-5. doi: 10.1016/j.drudis.2007.04.006.
Yanhong Shi 1
Affiliations

Affiliation

  • 1 Division of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA. yshi@coh.org
Abstract

Orphan nuclear receptors provide a unique resource for uncovering novel regulatory systems that impact human health and also provide drug targets for a variety of human diseases. Ligands of nuclear receptors have been used in several important therapeutic areas, such as breast cancers, skin disorders and diabetes. Orphan nuclear receptors, therefore, represent a tremendous opportunity in understanding and treating human diseases. Here, I highlight recent advances in the use of orphan nuclear receptors and their potential as targets for drug discovery in diabetes, obesity, neurodegenerative diseases and Other related disorders.

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