1. Academic Validation
  2. Cytotoxic ent-kauranoids from the medicinal plant Isodon xerophilus

Cytotoxic ent-kauranoids from the medicinal plant Isodon xerophilus

  • J Nat Prod. 2007 Aug;70(8):1295-301. doi: 10.1021/np070205m.
Li-Mei Li 1 Zhi-Ying Weng Sheng-Xiong Huang Jian-Xin Pu Sheng-Hong Li Hao Huang Bing-Bing Yang Yu Han Wei-Lie Xiao Ma-Lin Li Quan-Bin Han Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Abstract

Bioassay-directed fractionation of the leaves of the medicinal plant Isodon xerophilus led to the isolation of a series of potential antitumor molecules. Thirteen new (1-13) and 23 (14-36) known Diterpenoids were isolated and identified, representing ent-kauranoids of several structural types. The structures of 1-13 were determined by means of spectroscopic studies. The absolute configurations of the new compounds were clarified by CD spectroscopic studies or were postulated on biogenetic grounds. All compounds obtained were evaluated for their cytotoxic activity against the K562, MKN45, and HepG2 cell lines. Compounds 1, 2, 11, 16-19, 23, 26-28, 30, and 32 demonstrated significant cytotoxic activity for one or more cell lines.

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