2. Academic Validation
  3. Isolation and identification of antiplatelet aggregatory principles from the leaves of Piper lolot

Isolation and identification of antiplatelet aggregatory principles from the leaves of Piper lolot

  • J Agric Food Chem. 2007 Nov 14;55(23):9436-42. doi: 10.1021/jf071963l.
Chia-Ying Li 1,  Wei-Jern Tsai,  Amooru Gangaiah Damu,  E-Jian Lee,  Tian-Shung Wu,  Nguyen Xuan Dung,  Tran Dinh Thang,  Le Thanh
Affiliations

Affiliation

  • 1 Department of Chemistry, National Cheng Kung University, Tainan, Taiwan.
PMID: 17941696 DOI: 10.1021/jf071963l
Abstract

The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to activity-guided isolation to yield twelve new amide Alkaloids, piperlotine A-L (1-12), along with twenty-nine known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds piperlotine A (1), piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl)propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-trans-cinnamoylpyrrolidine (24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity.

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