2. Academic Validation
  3. Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

  • Bioorg Med Chem. 2008 Mar 15;16(6):3291-301. doi: 10.1016/j.bmc.2007.12.014.
Christine M Wright 1,  Raj J Chovatiya,  Nora E Jameson,  David M Turner,  Guangyu Zhu,  Stefan Werner,  Donna M Huryn,  James M Pipas,  Billy W Day,  Peter Wipf,  Jeffrey L Brodsky
Affiliations

Affiliation

  • 1 Department of Biological Sciences, University of Pittsburgh, 274 Crawford Hall, Pittsburgh, PA 15260, USA.
PMID: 18164205 DOI: 10.1016/j.bmc.2007.12.014
Abstract

The HSP70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast Cancer. HSP70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described HSP70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of HSP70.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-12619
    HSP70 Inhibitor
    HSP