2. Academic Validation
  3. Further cytotoxic sesquiterpene lactones from Elephantopus mollis KUNTH

Further cytotoxic sesquiterpene lactones from Elephantopus mollis KUNTH

  • Chem Pharm Bull (Tokyo). 2008 Feb;56(2):231-3. doi: 10.1248/cpb.56.231.
Turibio Kuiate Tabopda 1,  Joseph Ngoupayo,  Jiawei Liu,  Muhammad Shaiq Ali,  Shamsun Nahar Khan,  Bonaventure Tchaleu Ngadjui,  Bang Luu
Affiliations

Affiliation

  • 1 Département de Chimie Organique, Université de Yaoundé I, BP 812 Yaoundé, Cameroun. ttabopda@yahoo.fr
PMID: 18239317 DOI: 10.1248/cpb.56.231
Abstract

Three new sesquiterpene lactones, (4betaH)-5alpha-hydroxy-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6alpha-olide (1), (4betaH)-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6alpha-olide (2) and 2,5-epoxy-2beta-hydroxy-4alpha-methoxy-8alpha-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide (3), have been isolated from roots and stems of Elephantopus mollis together with two known sesquiterpene lactones (4, 5). The identification of the isolates was accomplished by spectroscopic methods. Compounds (1-5) exhibited significant cytotoxic activities against mouse neuroblastoma B104 cells.

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