2. Academic Validation
  3. Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity

Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity

  • Arch Pharm Res. 2008 Mar;31(3):318-22. doi: 10.1007/s12272-001-1158-9.
Ming Shan Zheng 1,  Nam Kyung Hwang,  Do Hoon Kim,  Tae Chul Moon,  Jong Keun Son,  Hyeun Wook Chang
Affiliations

Affiliation

  • 1 College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea.
PMID: 18409044 DOI: 10.1007/s12272-001-1158-9
Abstract

In our ongoing search for anti-inflammatory agents originating from Korean medicinal Plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole Plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, alpha-spinaterol (1), ursolic acid (2), ergosterol peroxide (3), alpha-spinaterol glucoside (4), 2-methoxy-9-beta-D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5-LOX activity with IC50 values of 21.04 microM, 42.30 microM, 32.82 microM, and 17.18 microM, respectively.

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