2. Academic Validation
  3. IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding

IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding

  • Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. doi: 10.1016/j.bmcl.2008.04.039.
George M Buckley 1,  Thomas A Ceska,  Joanne L Fraser,  Lewis Gowers,  Colin R Groom,  Alicia Perez Higueruelo,  Kerry Jenkins,  Stephen R Mack,  Trevor Morgan,  David M Parry,  William R Pitt,  Oliver Rausch,  Marianna D Richard,  Verity Sabin
Affiliations

Affiliation

  • 1 UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
PMID: 18482836 DOI: 10.1016/j.bmcl.2008.04.039
Abstract

A potent IRAK-4 inhibitor was identified through routine project cross screening. The binding mode was inferred using a combination of in silico docking into an IRAK-4 homology model, surrogate crystal structure analysis and chemical analogue SAR.

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