2. Academic Validation
  3. Structures of two novel heterocyclics from Whitmania pigra

Structures of two novel heterocyclics from Whitmania pigra

  • Planta Med. 2008 Apr;74(5):562-4. doi: 10.1055/s-2008-1074493.
Yun-Feng Zheng 1,  Xian-Feng Huang,  Guo-Ping Peng
Affiliations

Affiliation

  • 1 Institute of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
PMID: 18543153 DOI: 10.1055/s-2008-1074493
Abstract

Two new heterocyclics, named hirudonucleodisulfide A (1) and hirudonucleodisulfide B (2), were isolated from the dried material of Whitmania pigra Whitman. Their structures were elucidated by various spectroscopic means in combination with X-ray crystallographic analysis. A biological assay in vitro against anoxic injury demonstrated that 1 and 2 have moderately anti-anoxic activity with EC (50) values of 27.01 +/- 2.23 microg/mL and 19.54 +/- 1.53 microg/mL, respectively.

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