2. Academic Validation
  3. Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

  • Bioorg Med Chem Lett. 2008 Jul 15;18(14):3856-9. doi: 10.1016/j.bmcl.2008.06.060.
Mark E Schnute 1,  Roger J Brideau,  Sarah A Collier,  Michele M Cudahy,  Todd A Hopkins,  Mary L Knechtel,  Nancee L Oien,  Robert S Sackett,  Allen Scott,  Mari L Stephan,  Michael W Wathen,  Janet L Wieber
Affiliations

Affiliation

  • 1 Global Research and Development, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. mark.e.schnute@pfizer.com
PMID: 18595689 DOI: 10.1016/j.bmcl.2008.06.060
Abstract

A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.

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