2. Academic Validation
  3. Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors

Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors

  • Antimicrob Agents Chemother. 2008 Sep;52(9):3433-7. doi: 10.1128/AAC.01534-07.
Jan Paeshuyse 1,  Inge Vliegen,  Lotte Coelmont,  Pieter Leyssen,  Oriana Tabarrini,  Piet Herdewijn,  Harald Mittendorfer,  Johnny Easmon,  Violetta Cecchetti,  Ralf Bartenschlager,  Gerhard Puerstinger,  Johan Neyts
Affiliations

Affiliation

  • 1 Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
PMID: 18625766 DOI: 10.1128/AAC.01534-07
Abstract

We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) alpha,gamma-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) Cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.

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