2. Academic Validation
  3. Anthracycline antibiotic 2-hydroxyaclacinomycins. II. Production of 2-hydroxyaclacinomycins A and B by a new recombinant strain and their antitumor activities

Anthracycline antibiotic 2-hydroxyaclacinomycins. II. Production of 2-hydroxyaclacinomycins A and B by a new recombinant strain and their antitumor activities

  • Jpn J Antibiot. 1991 Mar;44(3):277-86.
A Yoshimoto 1,  O Johdo,  T Ishikura,  T Takeuchi
Affiliations

Affiliation

  • 1 Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
PMID: 1880910
Abstract

Anthracycline Antibiotics 2-hydroxyaclacinomycins A and B were isolated and purified from the culture broth of a recombinant strain which was produced by protoplast fusion of two aclacinomycin-blocked mutants. 2-Hydroxyaclacinomycin B is a new compound for which chemical structure and the biological activity in vitro were determined. 2-Hydroxyaclacinomycins had a stronger antitumor activity against murine leukemic L1210 cells in mice than the parent Antibiotic aclacinomycins.

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