2. Academic Validation
  3. Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol

Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol

  • Bioorg Med Chem Lett. 2008 Oct 15;18(20):5387-90. doi: 10.1016/j.bmcl.2008.09.053.
Kenneth O Eyong 1,  Ponminor S Kumar,  Victor Kuete,  Gabriel N Folefoc,  Ephriam A Nkengfack,  Sundarababu Baskaran
Affiliations

Affiliation

  • 1 Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India.
PMID: 18829316 DOI: 10.1016/j.bmcl.2008.09.053
Abstract

Ozonolysis of lapachol (1), resulting in an unusual formation of a potent antitumor agent 2-acetylfuranonaphthoquinone (3) along with the expected aldehyde 6, is described. The reaction of lapachol (1) with CAN in dry acetonitrile leading to biologically active furanonaphthoquinones is also reported. The antitumoral activity of the tested compounds on human DU-145 prostate carcinoma cells was evaluated following XTT assay. The results revealed that 2-(1-methylethenyl)-2,3-dihydronaphtho[2,3-b]furan-4,9-dione (5), beta-lapachone (10) and dehydro-beta-lapachone diacetate (11) showed 100% inhibition at 25 microg/ml. All the tested samples showed dose-dependent activity.

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