2. Academic Validation
  3. Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida

Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida

  • Bioorg Med Chem Lett. 2009 Jan 1;19(1):77-9. doi: 10.1016/j.bmcl.2008.11.014.
Biswanath Das 1,  Kongara Ravinder Reddy,  Bommena Ravikanth,  Tuniki Venugopal Raju,  Balasubramanian Sridhar,  Patan Usman Khan,  Janapala Venkateswara Rao
Affiliations

Affiliation

  • 1 Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India. biswanathdas@yahoo.com
PMID: 19036584 DOI: 10.1016/j.bmcl.2008.11.014
Abstract

Chemical examination of the stems of Jatropha multifida afforded a novel lathyrane-type diterpene, multifidone, having an unusual six-membered A ring. The structure of the compound was determined from detailed analysis of its 1D and 2D NMR spectra and X-ray crystallographic analysis. Its cytotoxicity was measured on four different cancerous cell lines.

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