2. Academic Validation
  3. Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives

Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives

  • Bioorg Med Chem Lett. 2009 Jan 15;19(2):489-92. doi: 10.1016/j.bmcl.2008.11.040.
Julie Charton 1,  Rebecca Deprez-Poulain,  Nathalie Hennuyer,  Anne Tailleux,  Bart Staels,  Benoit Deprez
Affiliations

Affiliation

  • 1 INSERM U761 Biostructures and Drug Discovery, 3 rue du Professeur Laguesse, Lille F-59006, France. julie.charton@univ-lille2.fr
PMID: 19058965 DOI: 10.1016/j.bmcl.2008.11.040
Abstract

We have successfully obtained 1,2,4-oxadiazol-5-one bioisoteres of Am580 or Tazarotene-like retinoids. In particular compound 4 displays an EC(50) of 26nM on RAR-beta.

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