2. Academic Validation
  3. Discovery of thiophene inhibitors of polo-like kinase

Discovery of thiophene inhibitors of polo-like kinase

  • Bioorg Med Chem Lett. 2009 Feb 1;19(3):1018-21. doi: 10.1016/j.bmcl.2008.11.041.
Kyle A Emmitte 1,  C Webb Andrews,  Jennifer G Badiang,  Ronda G Davis-Ward,  Hamilton D Dickson,  David H Drewry,  Holly K Emerson,  Andrea H Epperly,  Daniel F Hassler,  Victoria B Knick,  Kevin W Kuntz,  Timothy J Lansing,  James A Linn,  Robert A Mook Jr,  Kristen E Nailor,  James M Salovich,  Glenn M Spehar,  Mui Cheung
Affiliations

Affiliation

  • 1 Oncology R & D, GlaxoSmithKline, Five Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA. kyle.a.emmitte@Vanderbilt.edu
PMID: 19097784 DOI: 10.1016/j.bmcl.2008.11.041
Abstract

The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.

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