1. Academic Validation
  2. Prenylated and benzylated flavonoids from the fruits of Cudrania tricuspidata

Prenylated and benzylated flavonoids from the fruits of Cudrania tricuspidata

  • J Nat Prod. 2009 Jan;72(1):164-7. doi: 10.1021/np800418j.
Xiang Hua Han 1 Seong Su Hong Qinghao Jin Dayu Li Hyun-Kyu Kim Jeongrai Lee Suk Hyung Kwon Dongho Lee Chong-Kil Lee Myung Koo Lee Bang Yeon Hwang
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
Abstract

Three new prenylated Isoflavones, 5,7-dihydroxy-6-(2''-hydroxy-3''-methylbut-3''-enyl)-4'-methoxylisoflavone (1), 5,4'-dihydroxy-6-(3''-methylbut-2''-enyl)-2'''-(4'''-hydroxy-4'''-methylethyl)-3'''-methoxydihydrofurano-[4''',5''';7,8]isoflavone (2), and 5,4'-dihydroxy-8-(3''-methylbut-2''-enyl)-2'''-(4'''-hydroxy-4'''-methylethyl)furano-[4''',5''';6,7]isoflavone (3), a benzylated dihydroflavonol, 5,7,4'-trihydroxy-8-p-hydroxybenzyldihydroflavonol (4), and eight known Flavonoids (5-12) were isolated from the fruits of Cudrania tricuspidata. The structures of these compounds were determined on the basis of MS and (1)H and (13)C NMR spectroscopic data, including 2D NMR experiments. Compounds 2, 3, 6, 7, 8, 10, 11, and 12 inhibited LPS-induced nitric oxide production, with IC(50) values of 11.8-41.8 microM.

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