2. Academic Validation
  3. Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

  • Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1530-5. doi: 10.1073/pnas.0811029106.
Lijuan Xu 1,  Nengming Xiao,  Feng Liu,  Hongwei Ren,  Jun Gu
Affiliations

Affiliation

  • 1 National Key Laboratory of Protein Engineering and Plant Gene Engineering, College of Life Sciences, Peking University, Beijing, China.
PMID: 19164550 DOI: 10.1073/pnas.0811029106
Abstract

gC1qR is one of the C1q receptors implicated in the regulation of innate and adaptive immunity. We found that gC1qR inhibits RIG-I and MDA5-dependent Antiviral signaling. Double stranded RNA and virus trigger the translocation of gC1qR to the mitochondrial outer membrane leading to the interaction of gC1qR with the RIG-I and MDA5 adaptor, VISA/MAVS/IPS-1/Cardif. The interaction of gC1qR with VISA/MAVS/IPS-1/Cardif at mitochondria results in the disruption of RIG-I and MDA5 signaling and the promotion of virus replication. Knockdown of endogenous gC1qR enhances RIG-I-dependent Antiviral signaling, and augments the inhibition of virus proliferation. Therefore, gC1qR is a physiological inhibitor of the RIG-I and MDA5-mediated Antiviral signaling pathway. These data uncover a new viral mechanism used to negatively control Antiviral signaling in host cells.

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