2. Academic Validation
  3. Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity

Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity

  • Circ Res. 2009 Feb 13;104(3):288-91. doi: 10.1161/CIRCRESAHA.108.190892.
Elvira Haas 1,  Indranil Bhattacharya,  Eugen Brailoiu,  Marlen Damjanović,  G Cristina Brailoiu,  Xin Gao,  Laurence Mueller-Guerre,  Nicole A Marjon,  André Gut,  Roberta Minotti,  Matthias R Meyer,  Kerstin Amann,  Emerita Ammann,  Ana Perez-Dominguez,  Michele Genoni,  Deborah J Clegg,  Nae J Dun,  Thomas C Resta,  Eric R Prossnitz,  Matthias Barton
Affiliations

Affiliation

  • 1 Departement für Innere Medizin, Klinik und Poliklinik für Innere Medizin, Universitätsspital Zürich, Rämistrasse 100, CH-8091 Zürich, Switzerland.
PMID: 19179659 DOI: 10.1161/CIRCRESAHA.108.190892
Abstract

We found that the selective stimulation of the intracellular, transmembrane G protein-coupled Estrogen Receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from Cardiovascular Disease and obesity.

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